Nutrition

Chemicals That Cause Belly Fat?

By Kevin DiDonato MS, CSCS, CES

There are hundreds, if not thousands, of chemicals produced every day.

The fact is, some of these chemical can be harmful to your health.

Chemicals have been linked to lower testosterone levels, altered hormone levels in infants and toddlers, and now these chemicals have been linked to different types of fat in your body.

Persistent organic pollutants, by definition, are chemicals that are found to be resistant to environmental degradation through chemical, biological, and photolytic processes, and have been linked to increased accumulation in human and mammal tissue.

Otherwise known as POPs, these harmful chemicals have been shown to disrupt your endocrine (hormone), reproductive, and immune systems.

Now, according to a new study published in the Journal of Obesity, these same POPs could lead to increased visceral adipose tissue, which may lead to increased health risks.

Let me explain…

POPs and Visceral Fat

Visceral adipose tissue, otherwise known VAT, has been shown in research to wrap itself around your internal organs.  They could also release pro-inflammatory molecules, therefore increasing inflammation levels in your body and fat cells.

Increased levels of visceral fat have been linked to different diseases including metabolic syndrome, diabetes, insulin resistance, and heart disease; also, visceral fat has been linked to the development of the pot belly in many individuals.

On the other hand, subcutaneous fat (SAT) has been shown to take on fatty acids and store them for later use, plus, produce and secrete powerful weight loss hormones, which have been shown to be beneficial to your health.

According to the authors of this study, they may have confirmed their own previous findings that POP chemicals and PCB chemicals may lead to increase visceral fat stores and increased disease risk.

The researchers wanted to investigate the relationship that POPs have on visceral and subcutaneous adipose tissue in human subjects.

They recruited 1,016 adults with an average age of 70 and who were participants in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

They analyzed 23 different POPs and assessed the abdominal fat (VAT and SAT) of 287 older adults using an abdominal MRI scan.

The researchers showed that the less chlorinated polychlorinated biphenyl (PCBs) congeners and the pesticides dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), and trans-nonachlordane (TNC) were positively related to both VAT and SAT.

They also noted that the more highly chlorinated PCBs were inversely related to VAT and SAT.

On an interesting note, they showed that PCB189 was related to VAT/SAT ratio in a U-shaped manner, which could be important in the development of diabetes.

From their work, they concluded that their results were in accordance with their previous study using waist circumference and fat mass as obesity measure.

They also noted in their conclusion that the relationship between PBC189 warranted further research, since the exposure to this PCB
has been linked in other research to the development of diabetes.

Although this research is new, much more research needs to be done in order to determine the impact that POP’s have on your health and wellness.  However, through studies like this, it could show a direct relationship in POP’s and negative health impacts.

Chemicals and Your Health

It has been shown by different research studies, that exposure to chemicals may be harmful to your health.

In fact, exposure to certain chemicals, such as PCBs and POPs, may result in immune, reproductive, and endocrine dysfunction.

Now, according to the results of this study, POPs may be linked to increase visceral adipose tissue, which could negatively impact your health in the future.

Reducing your exposure to these harmful chemicals may improve your health, plus in combination with the right diet and exercise plan, may reduce your visceral adipose tissue and reduce your risk for other chronic diseases

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Top 10 Diet Fallacies

Top 10 Diet Fallacies

By: Ori Hofmekler

Ori Hofmekler is an exercise and nutrition researcher who has some very strong beliefs about diet. His mission is to expose some of the fallacies and misinformation that exist on the subject of proper nutrition and eating habits. While his views are controversial, and you (and many here at IRON MAN) may not agree with everything he says, Hofmekler’s points are critical food for thought.

Ori Hofmekler is the author of the books The Warrior Diet and Maximum Muscle & Minimum Fat, published by Dragon Door Publications

FALLACY 1
Breakfast is the most important meal of the day.

Contrary to what you may have been told, morning is the worst time to eat. When you wake up, your body is already in an intense detox mode, clearing itself of the endotoxins and digestive waste of the previous evening’s meal. During the morning hours, when digestion is fully completed (while you’re on empty), a primal survival mechanism known as the fight-or-flight reaction to stress is triggered, maximizing your body’s capacity for generating energy, being alert, resisting fatigue and resisting stress. The survival mode is primarily controlled by a part of the autonomic nervous system known as the sympathetic nervous system, or SNS. When it’s in gear, the body is in its most energy-producing phase, and that’s when the most energy comes from fat burning. All that happens when you do not eat the typical morning meal.

If you do eat a breakfast of, say, bagel, cereal, egg and bacon, you’ll most likely shut down this energy-producing system. The SNS and its fight-or-flight mechanism will be substantially suppressed, and your morning meal will trigger an antagonistic part of the autonomic nervous system known as the para sympathetic nervous system, or PSNS. The PSNS will make you sleepy, slow and less resistant to fatigue and stress. Instead of spending energy and burning fat, your body will be more geared toward storing energy and gaining fat. Under those conditions detox will be inhibited, and the overall metabolic stress will increase, with toxins accumulating in the liver, giving your body another substantial reason to gain fat: It stores the toxins in fat tissues.

The suppressing effects of morning meals often lead to energy crashes during the daytime hours, when you’re working, bringing frequent cravings for pick-me-up foods and substances like sweets, coffee and tobacco. Eating at the wrong time severely interrupts the body’s ability to be in tune with the circadian clock. The human body has never adapted to such interruptions. We are primarily programmed to rotate between the two autonomic nervous system parts: The SNS regulates alertness and action during the day, while the PSNS regulates relaxation, digestion and sleep during the night.

Any interruption in the cycle may lead to sleepiness during the day, followed by sleeping disorders at night. Morning meals must be carefully designed not to suppress the SNS and its highly energetic state. Confining morning food intake to fruit, veggie soups or small amounts of fresh light protein foods, such as poached or boiled eggs, plain yogurt or white cheese, will maintain the body in an undereating phase while promoting the SNS with its energy-producing properties.

Note: Athletes who exercise in the morning should turn breakfast into a postexercise recovery meal’small amounts of fresh protein foods plus carbs; for example, yogurt and a banana, eggs plus a bowl of oatmeal, or cottage cheese with berries. An insulin spike is necessary to effectively finalize the anabolic actions of growth hormone and insulinlike growth factor 1 after exercise, but after the initial recovery meal you want to maintain your body in an undereating phase by minimizing carb intake in the meals that follow. Applying small protein meals’with minimum carbs’every couple of hours will sustain the SNS during the day while providing amino acids for protein synthesis in muscle tissue, promoting a long-lasting anabolic effect after exercise. Breakfast isn’t the most important meal of the day; that distinction goes to your postexercise recovery meals. It’s when you eat that makes what you eat matter.

FALLACY 2
Eating before exercise will give your muscles instant energy.

It’s been generally assumed that the human body operates like a machine, so in order for it to work, it must be fueled like a machine. Eating before exercise seems to make sense. But does it really?

In order to give the muscle nutrients and energy, food must be fully digested. Digestion is the process in which the body breaks food down into smaller compounds, yielding molecules of amino acids, fatty acids and glucose that are transferred to the body’s tissues through the circulatory system. The digestion-and-elimination process, which occurs in the stomach, intestines, liver and kidneys, requires substantial amounts of energy. During digestion, blood flow shifts from the brain and muscles to the above organs, which profoundly affects the brain and muscle tissues, lowering their capacity to perform work and resist fatigue.

What about meals that require almost no digestion, such as those made from fast-assimilating nutrients? Fat is digested and assimilated more slowly than protein or carbs, but is a preexercise meal of fast-releasing proteins and carbs (such as whey and sugar) the way to go? In theory such a meal should nourish the muscle tissues with amino acids and glucose to inhibit muscle breakdown and provide instant energy. It all makes sense, but in real life things often work differently from the way they work in theory.

Recent studies have demonstrated that eating fast-releasing foods before or during exercise could be counterproductive, to say the least. Investigators at the School of Sport and Exercise Science, University of Birmingham, in England, found that eating carbs before exercise adversely elevated plasma cortisol levels. And there was a significant reduction in postexercise cortisol when subjects didn’t eat carbs before exercise. Furthermore, there was a faster shift from carb burning to fat burning during exercise if there was no preexercise meal.

What has failed to reach mainstream nutrition awareness is the fact that protein-rich foods raise cortisol if applied incorrectly. Studies at the University of Lubeck in Germany found that eating fast-releasing protein foods, such as hydrolyzed, or predigested, proteins, before exercise has an even more profound cortisol-elevating effect than whole-protein foods. Note that chronic elevated cortisol has been associated with muscle waste and fat gain, particularly abdominal fat.

So a preexercise meal may rob the brain and muscles of energy due to the digestion process, but eliminating the digestion effect of the meal may only make things worse by elevating cortisol, compromising your ability to build muscle and burn fat.

Ironically, the same meal that appears to be counterproductive when eaten before exercise can be most beneficial when applied after exercise. Numerous studies have demonstrated the positive effects of postexercise recovery meals on total muscle recuperation’energy replenishment and increased protein synthesis. Recent studies at the University of Texas Medical Branch, in Galveston, revealed that applying fast-releasing proteins and carbs after exercise had substantial anabolic effect on stimulating net muscle protein synthesis, even in cases of elevated cortisol.

FALLACY 3
Eating late will make you fat.

It’s often said that night is the worst time to eat. The logic: Night is when the body typically slows down and, therefore, is more prone to gain fat. Makes sense, but is it true?

There are no conclusive studies or any evidence to prove that eating late causes more fat gain than eating early. Studies reveal that other variables, such as the frequency of meals, the glycemic index of food, calorie intake and hormonal balance are the real power brokers in the body’s capacity for burning or gaining fat.

Even so, the notion that eating late causes fat gain is deep rooted. For most people, who typically eat several meals during the day, a late meal may be an additional meal, and any additional meal may be one too many. The result can be fat gain. Does it mean that eating late is a bad idea? Quite the opposite. If you plan your meals properly and the evening meal turns out to be the main meal, then eating late can be highly rewarding.

There’s a substantial amount of evidence that humans have adapted well to nighttime eating. We carry the genes of our hunter-gatherer ancestors, who were busy gathering and hunting during the day and eating at night, when they were at rest. Indeed, our bodies are biologically programmed to work around the circadian clock’active during the day and relaxing at night. As mentioned above, our inner clocks are controlled by the two antagonistic autonomic nervous systems, with the result that our bodies digest and use nutrients better at night than during the highly stressful hours of the day. What’s more, night is the time when growth hormone peaks (peak secretion occurs during non-REM, SWS deep sleep). GH is known to be a potent muscle-and-bone builder and a fat burner. Late meals, if applied correctly, can be highly anabolic.

Note that GH actions cannot be effectively finalized without the interference of insulin. Eating late may well help you take advantage of max GH spike during the night, promoting protein synthesis in the muscle tissues and fat burning by providing the nutrients required for facilitating GH actions. Do not betray your biological destiny. Don’t deny yourself late meals. If you do, your body may come back with a vengeance to reclaim what was taken away from it. The effects often include chronic cravings for food at night, which may result in bingeing. Finally, late meals often have a relaxing effect on the body, preparing you for sleep. If nothing else, they can help bring a happy end to a tough day.

FALLACY 4
Fat makes you fat.

The claim that ‘Fat is fat and therefore makes you fat’ isn’t theoretically incorrect, but in real life it’s misleading. Dietary fat consists of a huge variety of fat molecules divided into groups and subgroups; each plays a different role in the body. Numerous studies have demonstrated the critical functions of essential fatty acids (EFAs), phospholipids and cholesterol compounds in regulating such functions as blood pressure, inflammation, lipid metabolism, stress reaction, buildup of cell membranes, nerve functions, immune actions and steroid hormone production. It’s clear that the role of dietary fat goes far beyond just being a fuel for energy or vehicle for storage.

The real question is, Do dietary fats convert efficiently into energy? Is the human body well adapted for using fat as an immediate fuel for energy? The answers aren’t simple, but even so, they’re yes and yes.

Studies at the Department of Clinical Biochemistry at the University of Cambridge Addenbrooke’s Hospital, in Cambridge, England, revealed that different people respond differently to a high-fat diet. Some mostly stored their excess fat calories, while others experienced increased total energy expenditure and fat oxidation with no fat gain. Why are some people more prone to gain fat from eating fat than others?

There’s a substantial body of evidence that certain variables profoundly affect a person’s capacity for using fat for fuel. Gender, frequency and intensity of exercise, source of dietary fat and diet composition are all on that list. Recent studies done at the University of Southern Denmark, in Odense, discovered that women have higher levels of lipid-binding proteins, with a higher capacity to use fat fuel in the muscle tissue, than men. Interestingly, the same studies found that men’s capacity for using fat in the muscles significantly increases when they increase exercise intensity.

The effect of exercise intensity on fat burning was further investigated at the University of Maastricht, in the Netherlands. Studies revealed that fat serves as a most efficient fuel in the form of intramuscular fat, which functions as an important and most effective substrate source of energy, particularly during prolonged intense exercise.

According to the thrifty genes theory (Journal of Applied Physiology. 96:3-10; 2004), humans have primarily adapted to survive cycles of famine and feast (essentially, undereating and overeating); exercise and rest. It has also been suggested that humans have adapted better to primal foods’foods on the bottom of the food chain, such as nuts, seeds and fertile eggs’than they have to later, top-of-the-food-chain fatty foods that come from farm animals (lard and butter, for example) or processing (margarine).

Based on those points, it’s been suggested that following a lifestyle that mimics primal feeding cycles and physical activity would most likely trigger the thrifty genes that help us better survive, making us more efficient at using fat and carb fuel with an increased resistance to fatigue, stress and disease. Primal-fat foods such as nuts and seeds are also good sources of amino acids and fat-soluble vitamins. In their raw state they contain phytosterols, which are cholesterol-like plant compounds that predominately support the production of sex steroid hormones.

To take advantage of nuts and seeds, eat them alone or with veggies and protein. Do not combine them with sugar or grains. Nuts and seeds are naturally low on the glycemic index, meaning that the nutrients are released slowly. Generally, the human body is better adapted to foods that have a low glycemic index number.

Thinking that fat can make you fat causes phobias that typically lead to extreme lowfat diets and severe consequences, including malnutrition, chronic fatigue, eating disorders, impotence, compromised immunity and fat gain.

FALLACY 5
Carbs are your enemy.

Carbs are currently regarded as the culprit responsible for the obesity epidemic in our society. The belief is that carbohydrates are not essential nutrients and therefore can be severely restricted or even eliminated from the diet. Low-carb-diet advocates argue that insulin is a bodyfat-promoting hormone and should be tightly controlled by chronically restricting carbs. Thanks to the current popularity of low-carb diets, everyone thinks carbs are the enemy. But are they? Nothing could be further from the truth.

Let’s examine the assumption that carbohydrate isn’t an essential nutrient. That fails to recognize the two most critical biological functions of carbohydrate (besides being a fuel): 1) the activation of the pentose phosphate pathway and 2) the finalization of growth hormone and insulinlike growth factor actions, as well as the enhancement of androgens actions.

The PPP is a critical process that’s responsible for the synthesis of DNA, RNA and all energy molecules, including ATP and NADPH, which are needed for all metabolic functions’in particular, recuperation (healing of tissues), immunity and growth. In addition, the PPP is a precursor for another metabolic pathway, the uronic acid pathway, which is responsible for steroid hormone transport, the production of proteoglycans (essential for connective tissue and cellular signaling), the synthesis of spingolipids (lipids that are necessary for neural protection) and overall detoxification. The pentose phosphate pathway, which occurs mostly in the liver, is derived from glucose, or carb metabolism. Here’s the problem:

When a desperate need for energy occurs, such as during prolonged starvation or due to chronic severe restriction of carbs, the PPP shuts down its main function and instead switches into sheer energy production. It’s likely that energy demand is a top priority for the body, and, therefore, in times of a desperate need for energy, the body would suppress certain important metabolic functions, such as the PPP, to accelerate immediate energy production. Note that 30 percent of glucose oxidation in the liver can occur via the PPP.

One may argue that glucose can be synthesized from fat or protein. Yes, but not enough! Since the synthesis of glucose from fat or protein, known as gluconeogenesis, is actually a very limited metabolic process that occurs mostly in the liver, any severe restriction of carbs, in particular in active individuals, may adversely suppress the PPP’s critical functions due to insufficient glucose supply during an increased energy demand.

The PPP actions also decrease with age, a fact that may contribute to the decline in steroid hormone production and the typical muscle waste associated with aging. So dietary carbs are necessary for the full activation of the PPP and its critical functions. Severe chronic carb restriction’below 70 to 100 grams a day for active individuals’may lead to an adverse suppression of the PPP, with an overall decline in the sex hormones, compromised immunity, impaired growth and accelerated aging.

Besides playing a vital role in the activation of the PPP, dietary carbs also help finalize the actions of the most anabolic agents, including growth hormone, IGF-1 and the sex steroid hormones. Studies at Stanford University in California and Helsinki University in Finland revealed that insulin is a potent promoter of IGF-1 and the sex hormones’ action. Researchers found that insulin helps finalize the anabolic actions of GH, IGF-1 and androgens by downregulating certain proteins that suppress both IGF-1 and androgen action, in particular in the muscle tissue. A recent study done at the University of Texas proved that postexercise carb supplementation taken with essential amino acids profoundly stimulated net muscle protein synthesis.

Interestingly, simple carbs had a more profound effect on enhancing anabolic actions after exercise than complex carbs. Nonetheless, as a general rule, the human body is better adapted to using complex carbs than simple carbs. Again, it’s when you eat that makes what you eat matter.

As you can see, the biological functions of dietary carbs go far beyond energy production. Chronic carb restriction may lead to total metabolic decline in the long run, with severe consequences that would affect survival’lack of capacity to regenerate tissues and procreate.

 

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Weight Loss Tips — How to Eat Dessert and Still Stay Skinny

Darya Pino, Ph.D

Ph.D trained scientist, San Francisco foodie and advocate of local, seasonal foods

Cutting processed foods and refined sugars out of your diet is arguably the most important dietary change you can make to improve health and lose weight. But will one slice of birthday cake inevitably tighten your pants and cut your life short?

Not necessarily.

Quality of life is hard to measure, but it certainly involves some balance between good health and hedonistic enjoyment of things that might not be perfectly healthy. The question is how we find this balance for ourselves, and how do we make sure our behavior helps us keep that balance?

The answer, of course, will be different for everyone. Competitive athletes have higher physical demands for maintaining ideal health than, say, a scientist. And I’m not a fan of watering down my favorite foods — especially desserts — with “healthier” ingredients. But there are a few general guidelines that can help the majority of us live a little without constantly fighting the battle of the bulge.

9 Tips For Dealing With Dessert

1. Eat dessert once per week or less

As a general rule I try to keep my dessert consumption to once per week or less (it is often less). A larger person may be able to get away with a bit more, but setting a weekly maximum can help you keep tabs on your sugar consumption. If you are actively trying to lose weight, aiming for once every two weeks or less is ideal.

Sugar is problematic for several reasons. Most of you probably realize by now that excess sugar causes rapid blood sugar and insulin spikes that force extra calories to be stored as fat. Over time these spikes will alter your sensitivity to insulin, negatively impacting your metabolism and risk of type 2 diabetes. Extra insulin signaling is also associated with heart disease, high blood pressure and accelerated aging.

The less refined sugar you eat the better, but assuming most of us aren’t willing to give it up completely it is helpful to have a weekly maximum to keep consumption in a reasonable range.

2. Pick your occasions

Once you decide to budget your sugar consumption, it is time to start choosing your priorities.

Is your weekly group meeting at the office (the one where there’s always doughnuts) really a special occasion? In other words, is that stale chocolate doughnut you wolf down while half asleep really worth the extra workout or skipping dessert with your kids this weekend? Probably not.

If you think about it, there’s a good chance you don’t even enjoy that doughnut as much as you assume you do. And we both know you’ll feel horrible after eating it anyway. So why do you believe that you want it?

When you stop and really think about your food choices, you’ll often find that many of them come from conditioning rather than true preference. But just because 12-year old you liked low-quality sweets doesn’t mean the adult you has to continue eating them.

Save desserts for the times that are really worth it, and realize you aren’t missing much by skipping the Costco brownie bites.

3. Don’t eat dessert alone

Special occasions are moments of celebration you share with people you care about. One of the wonderful things about life is these moments happen all the time. Our weeks and months are perpetually marked by birthdays, weddings, promotions, vacations and a million other reasons to celebrate. Use these special times as cues for when to indulge.

On the other hand, there is nothing particularly special about sitting alone on your couch watching TV. Try to get out of the habit of eating dessert alone, especially if this is something you rely on for comfort. If you just want something sweet, try having a piece of fruit or some herbal tea instead.

I recommend not keeping any pre-made desserts in the house at all. Why torture yourself?

4. Know dessert when you see it

If you’re eating dessert several times a day but only think you are eating it once or twice per week, none of these rules are going to help you maintain your health and physique.

There are clearly benefits to eating a salad, but syrupy dressings contribute to your sugar intake whether there is lettuce around or not. Overly sweet non-dessert foods make it more difficult for you to enjoy real indulgences without consequences.

Be aware of the sugar content in the foods you eat and actively try to minimize it in the bulk of your diet (i.e. choose sandwiches without teriyaki or BBQ sauce, salads with savory (not sweet) dressing, cocktails without juice or syrup, and plain yogurt).

If you’re eating healthy and minimizing sugar 90+ percent of the time, your waist will hardly notice the occasional birthday cupcake.

5. Little indulgences count

Just as you cannot ignore the 27 grams of sugar in Yoplait yogurt, you can’t grab two or three pieces of candy every afternoon from the bowl in the office without it adding up.

Be aware of the little cheats you make throughout the week and don’t kid yourself about their impact. If you decide that the work day is just too hard to get through without these, that’s fine. But you aren’t doing yourself any favors by pretending they don’t exist. Remember to count them in your mental dessert tally and keep it in mind when you’re looking lustfully at your grandma’s homemade apple pie and wishing you hadn’t had so much sugar this week.

6. Choose quality over quantity

If your goal is to limit your sweets but you don’t want to feel like you’re missing out, make sure your choices emphasize quality over quantity.

A few bites of good quality dark chocolate is infinitely more satisfying than a handful of Hershey’s kisses. Desserts can rack up 25-100 calories per bite. Get the most bang for your buck by picking foods with actual flavor and not just extra sugar and salt.

Hint: This tip should also help you stick to tips #2 and #5.

7. Go splitsies

Half a dessert is 100 percent better for you than a whole dessert.

If you really really want to try one of those cookies your co-worker has been bragging about for months but have already had your ice cream this week, try taking only half of one. Better yet, find someone to split it with you so you aren’t tempted to finish it. If it’s that good, a few bites should be plenty satisfying.

8. Resist peer pressure

Some people take a special pleasure in encouraging others to do things they know are bad for them. These people also tend to be good at recruiting others to join in their banter.

Be prepared to get nagged occasionally for not wanting to eat foods that aren’t worth it. But if you have decided in advance to stick to desserts you know taste better than what your friends are pushing, it really isn’t that hard to ignore them.

Who’s really missing out here?

9. Use the gym

Despite our best efforts, we all eat too much dessert every now and then. This isn’t good, but it isn’t the end of the world either.

When this happens to me I use it as an opportunity to amp up my workout routine. By far my best runs are on days when we have birthday cake in lab — I feel like I can run for days with all my extra energy.

Your muscles use sugar as fuel, so use it up while you can and give your metabolism a little boost (having a little extra blood sugar and insulin around when you’re exercising can actually improve your metabolism) and prevent those spare calories from being stored as fat.

You’ll probably feel better after working it off too.

How do you deal with dessert in your healthstyle?

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Gene Test Claims To Show What Diet Works Best

by MARILYNN MARCHIONE

Diet not working? Blame your genes. That’s the pitch behind a new test that claims to show whether people will do better on a low-fat or a low-carb weight loss plan.

We’re all hard-wired with DNA that controls how we burn and store calories from various foods, and the test claims to sort out this machinery. A study this week found that women on diets well-matched to their genes, as defined by the test, lost roughly five times more weight than those on mismatched diets.

“We were able to explain why some people were successful” and others were not, even though they ate the same way, said Mindy Dopler Nelson, a nutritional biologist at Stanford University who led the study but has no financial ties to the maker of the test.

Some scientists find this hard to swallow. It’s another test being peddled without enough research to show it really works, they say.

“I’m afraid this may be another attempt to lure the public into purchasing genetic tests that provide little value for those struggling with their weight,” said Raymond Rodriguez, director of the National Center of Excellence for Nutritional Genomics at the University of California, Davis.

The research shows “nothing that should move the American public out to get their genome tested,” said Dr. Robert Eckel, a former American Heart Association president and cardiologist at the University of Colorado-Denver.

But it sure has appeal.

Gene testing originally was aimed at finding risk for things like cancer, diabetes and Alzheimer’s disease. Lately, genes have been linked to things you might not suspect, such as stuttering or compulsive leg-jiggling.

The latest trend is to connect genes to lifestyle counseling, determining what type of diet or exercise is best. That’s what the maker of the new diet test hopes to do.

 The company, Waltham, Mass.-based Interleukin Genetics Inc., looked at studies on hundreds of genes and chose three genes that show a pattern for metabolizing fats and carbohydrates, said its chief scientific officer, Ken Korman.

The company then hired Stanford researchers to do a validation study of its $149 test, using people who took part in diet research that was published in 2007. That study tested four diets – Atkins (ultra-low-carb), the Zone (low-carb), Ornish (very low-fat) or a low-fat diet following the federal Food Pyramid.

About one-third of the original participants, 138 women, sent cheek swabs with their DNA to Interleukin, which tagged them as “low-carb appropriate” or “low-fat appropriate.”

Looking back at the original study’s results, researchers saw that women whose diets matched their genetic makeup lost more than 13 pounds over a year compared to less than 3 pounds for women on mismatched diets, Nelson reported at a heart association conference this week.

Some scientists were unpersuaded. Sticking with a diet is more important than what diet you choose, as is not regaining weight, Eckel said.

“I have serious reservations with this study and studies like it,” Rodriguez agreed. “The idea that genetic variants in these genes can predict the likelihood for weight loss in such a small population, particularly since the tendency for weight loss is probably more behavioral than genetic, is simply hard to believe.”

However, one of the study participants, Jacqueline Gardner, 55, of Evergreen, Calif., does believe. She went from 200 pounds at the start of the study to 185, but was back to 200 pounds two years later.

“I now know why I gained it back,” she said – the gene test showed she does not metabolize carbohydrates well. More recently, she has been on a high-protein diet and weighs 180.

“I wish I had had a DNA test 10 years ago,” she said.

The researchers also tested themselves.

“It confirmed my suspicion,” Nelson said of her result. “When I eat a lot of carbohydrates, I tend to put on weight.”

Do we really need a gene test to tell us that?

UC Davis nutrigenomics center: http://nutrigenomics.ucdavis.edu

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Why You Should Know Your Genetic Health Profile

by Zippora Karz

Author The Sugarless Plum, Former soloist ballerina, New York City Ballet

If you knew you had the genetic marker for a certain disease, would it make the difference to motivate you to change your lifestyle and get healthy? I’m asking the question because I recently did an interview with AccessDNA, a web site devoted to helping people understand the genetics and inheritance of both rare and common disease. The hope is that knowing one’s susceptibility might help them to make more informed decisions about their disease management, treatment, screening and even prevention options.

Since I have lived with insulin dependent diabetes for 23 years this was the question they asked me:

AccessDNA: There is a lot of debate about testing young children for genetic susceptibilities to diseases such as heart disease and diabetes. Proponents of testing argue that knowing this information helps them modify their children’s diet and avoid any known risk factors from a young age. Opponents argue that a healthy diet and lifestyle should be encouraged for all children regardless. If you could have known from a young age that you had genetic markers associated with susceptibility to type 1 diabetes, do you think it would have impacted how your parents raised you?

Zippora: It’s hard to say how it would have impacted the way my parents raised me. They thought they were doing things right back then. The truth is that certain studies were not out. I’ve seen studies about milk and juvenile diabetes as well as vitamin D deficiency and diabetes. But neither of those studies were out then. So we would not have known to look for them. I did drink a lot of milk, and recently I was low in Vitamin D. I think so much has changed recently that today parents have much more information than we ever had. But we did eat well and we exercised a lot! Besides my daily ballet lessons, we used to run around at recess, and we played outside after school everyday. So I’m not really sure what my parents could have done differently with the information available at that time.

With that said, if it were today, they could check blood sugar levels, vitamin D levels, and even food allergies like to wheat and gluten. When I was diagnosed 23 years ago doctors were prescribing a high carbohydrate diet. Today it is mainstream to eat lower carbs, which is good for diabetes. I think if someone knows they are susceptible, it very well may make the difference for them to make healthy life changes, because we have the right information available now!

It is an interesting question and I do see both sides of the debate. I wish that every parent would feed their children healthy foods and encourage exercise that is fun regardless of any knowledge of genetic predisposition. And equally, I would hope each of us would take care of ourselves without the threat of some dismal outcome. But reality does not prove this to be true.

Just the other day, Francis Collins, the Director of the National Institutes of Health, was a guest on Charlie Rose, looking about 20 pounds thinner. Charlie commented on the dramatic change since last seeing his friend, even wondering if he was okay. It turns out Francis had discovered that he had the genetic markers for diabetes, and so he had begun to take the steps necessary to counter this predisposition. The knowledge that people who are overweight and inactive are at risk for diabetes was not enough in itself to get him to exercise and cut out sweets, Francis needed this extra incentive.

I’m not sure how many people would be as motivated as he was to finally change their potentially unhealthy behavior solely based on genetic marker information. But I do suspect if a parent were to find out their child might come down with a dreaded disease should the family not make changes, change would occur. While we may not always be willing to alter our own bad habits, most of us would do almost anything to save our loved ones from suffering.

We all know we should eat nourishing foods, exercise, and learn to handle stress, regardless of our genetic or hereditary susceptibility to any particular condition. But many of us find it difficult to consistently follow a healthy enough regimen. Perhaps access to information about our innate physiological tendencies might be just the right trigger to push us out of denial and into reality.

I know it can be frightening to discover you have higher than normal odds of coming down with a disease. But, believe me, it’s far worse to deal with an illness once you have it, than it is to make the changes necessary to prevent a disease from manifesting in the first place!
See my full interview with AccessDNA here.

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