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Ghrelin: Why You Get Hungry

Why are you always hungry?

Your hunger and your appetite are regulated by your endocrine system, but how it manages this has always been something of a mystery. We originally suspected that a rapid rise in insulin, followed by a fall in blood sugar, stimulated appetite—and overeating (for an excellent description of this outdated theory, see reference 1, pages 65-66).

 

Upon reviewing the available evidence, scientists specializing in appetite began to have their doubts about this mechanism’s ability to induce overeating[2-3], but realistic alternatives to this theory were lacking. This changed in 1999 with the discovery of the hormone ghrelin[4-5].

A product of the gut[6-17], ghrelin was the first hormone discovered to directly stimulate hunger in humans[18]. Ghrelin’s potential to regulate body weight has since led to rigorous investigation into its properties. Here’s a summary of the most important of these:

  • Stimulates growth hormone release in humans[4, 19-29], and is possibly the most potent stimulator of growth hormone release in the body[30]. Few conflicting results exist[30-31].
  • Higher concentrations directly increase hunger[18, 32-39].
  • Levels fall after meal ingestion[33, 34, 37, 38, 40-46]
  • Directly related to body mass[20, 47-61]; the more fat mass, the lower the levels of ghrelin.
  • Higher levels are found in women[40, 49, 62].
  • Possible role in male sex hormone production[63-65].

These properties of ghrelin position it high on the list of body weight regulators[18, 66-68], especially since it signals overall fat stores and nutritional status of the body[39, 48, 69-72]—i.e., the more fat you possess and the more you eat, the lower your levels of ghrelin.

Ghrelin appears as a direct link between the gut and the brain[73-76], and there’s even evidence that it causes a timing effect for meal ingestion during the day[77]. It may also even trigger a deeper state of sleep in humans[78]. Even the success of gastric bypass surgery to reduce weight seems to be related to ghrelin secretion—or a lack thereof[51, 58, 79, 80].

Long story short, this is a hormone requiring particular consideration in any type of diet, whether you’re a serious athlete or not[81]—and it’s definitely a hormone we’re going to target for manipulation.

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Meal Frequency: Finding The Body Composition Sweet Spot

Feel like you eat all the time but are never satisfied? Take a hard look at your meal planning and caloric distribution.

“Eat 4-6 meals per day to rev your metabolism and burn more calories.”

How many times have you heard that? Plenty, I imagine. In bodybuilding circles, this often gets expanded to 6-8 meals. I even saw a Mr. Olympia diet article where the reigning champ was eating 10 meals per day.

I get the logic. More is better. Keep fueling the metabolic furnace. But do we? When a dietary system like this places such strict demands on our lifestyles, we need to re-examine our habits and the science that drives them.

I found that fitness and bodybuilding people could benefit from eating less often, and people just starting out on their weight-loss or bodybuilding journey benefit from eating more often. But no matter which camp you’re in, I recommend building an eating plan based around your caloric needs, rather than arbitrarily using a number you hear mentioned by someone else.

How should you begin to do that? Let’s break it down.

Why Six Times Per Day?

I’ll be blunt: There’s not really any good data supporting hyper-metabolic effects of multiple meals.

One study published in International Journal of Obesity found that consistently eating more frequently—six times per day, to be specific—led to a greater “thermic effect” from food than eating sporadically. The thermic effect of food is basically the amount of energy it takes for your body to break down, digest, and process, the energy (food) you ingest.

In this study, frequent meals were linked to a statistically significant increase in the thermic effect of food, e.g. calorie-burning, but it wasn’t enough to draw significant conclusions in the realms of physique or body composition. Additionally, there wasn’t anything in the study to indicate that eating three, four, or five meals were worse than six—only that it was better than “sporadic” eating.

That is pretty much all the data you’ll find on meal frequency and boosting metabolism. For this reason, I make meal frequency recommendations for my clients based on two major factors: protein synthesis and satiety.

Meals Gained ≠ Muscle Gains

OK, so the science isn’t there, but everyone else seems like they’re doing it, so it can’t cause any harm, right? If your goal is maximum protein synthesis, I think there is a definite downside to eating often.

The first problem I see people run into when they eat frequently is that their blood amino acid levels are constantly elevated. In order to optimize protein synthesis you need to give your body a solid serving of protein which boosts protein synthesis and subsequently causes your blood amino acid (specifically leucine) levels to drop. To maximize synthesis, you should then hit your body with more protein while the levels are lower.

If you eat non-stop—every hour or two—then you aren’t going to experience the fluctuation in blood amino acid levels you need to optimize muscle growth. You need to space your meals out sufficiently in order to get the maximum amount of protein synthesis out of the food you eat.

Another issue that you run into is meal size. On one hand, it’s true that protein content plays a big role in satiety. Protein’s presence in the digestive track triggers the release of the hormone cholecystokinin (CCK), which signals to your brain that you’ve eaten and should be satisfied. However, meal size has been shown to be more important than protein content when it comes to satiety. If you eat too often, your meals will be so small that despite being protein-rich, they won’t satisfy you.

So you’re hungry—so what? Seriously, that is no way to live! If you’re going to go to all the trouble to eat all those meals, you should at least feel full. If you don’t, well, good luck sticking with your plan through the endless hours of prep and planning.

How Frequent Is Frequent Enough?

Some simple math can help us here. When looking to optimize anabolism and satiety, the number meals you eat throughout the day should be a divisor of the total amount of calories you eat.

If you eat 3,000 calories per day, then breaking that into five 600 calorie meals would probably give you sufficient food to feel satisfied, while not demanding so much that you need to turn to lower quality foods in order to hit your per-meal calorie targets. On the other hand, if you eat only 2,000 calories per day, eating five 400-calories meals is not a satiating option, but eating four 500-calorie meals would be more filling.

Each of these meals should contain a minimum of 30 grams of protein (the amount which research has shown is necessary to maximally stimulate protein synthesis). This pulse of protein can also be effectively spaced out and repeated throughout the day for the biggest increases in protein synthesis. If your calories are so low that you can’t get 30 grams of protein at each meal, sprinkle on a little leucine or have a BCAA drink with your meal to cover your bases in the protein synthesis department.

Remember when planning these meals that size is directly connected to satiety, so don’t make them too small to be filling. Not a big-time planner? You can still do this. Just eat a solid, protein-rich meal every 3-4 hours, and you’ll be more or less on track.

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7 Serious Diseases with Back Pain as a Symptom

7 Serious Diseases with Back Pain as a Symptom

(and a FREE Solution!)

By Jesse Cannone

What if it’s not just a backache?

Back pain should always be taken seriously. What you may have written off as “strain” or “overwork” could actually be an early warning sign of a major health problem.

That’s because it’s not always your muscles causing back pain. When you’re taking care of your back but still having pain, it’s time to look at other potential problems.

Your back pain could be caused by your gut, an infection, or even an inflammatory disorder you can’t see. The pain and tenderness you feel are your body’s way of screaming out for help.

Perhaps you’ve been avoiding doctors to cut costs. That’s great since there are many alternatives to drugs and surgery out there. But to make the best choices for your health, you truly need to listen to what your body is telling you.

To help you tune in to what you need to hear, here’s a quick guide to seven serious diseases your back pain could be telling you to watch out for now.

#1 Irritable Bowel Syndrome (IBS)

Lower back pain and back cramping are associated with Irritable Bowel Syndrome. Depending on who you ask, IBS affects between 3% and 20% of the population at some point in their lives. What everyone can agree on though is IBS will make your life miserable.

IBS is caused by bacterial invasions, inflammation, and chemical sensitivities that often get worse with age. Until you can bring your gut back to health, you’ll fight bloating, cramps, alternating bouts of diarrhea and constipation, painful pressure, and of course – back pain!

#2 Ulcerative Colitis

Who wants to have a part of their intestines removed? No hands? Good, so pay attention to lower back pain that might indicate yet another painful bowel disorder.

Ulcerative colitis affects around 700,000 Americans each year. Scientists are still looking for the cause, but at least the effects are well recognized. Ulcers in the lining of your intestines caused by this disease can lead to severe internal bleeding, a hole in your colon and increased risk of colon cancer.

For this one, your back pain may appear at the same time as blood in your stools, cramping and fever. It’s not the flu, and it won’t go away without treatment.

#3 Inflammatory Arthritis

Over 2 million people in America suffer from inflammatory arthritis. While you many watch for the signs of arthritis as they grow older, inflammatory arthritis can hit you at any age – and back pain can give you a heads up that it’s moving in.

Inflammatory arthritis can go after spinal spaces and joints, causing pain and stiffness that’s worst in the morning or after you’ve been sitting for a while. Your back and other joints may feel swollen and warm to the touch. Particularly if you’re under 40, you’ll want to pay attention to this pain and start fighting the inflammation to keep your joints flexible and mobile for the rest of your life.

#4 Kidney Infection

Kidney infections don’t always carry the same obvious symptoms as a bladder infection. Instead, you’re likely to notice lower back pain and tenderness in the kidney area as an early warning that something is wrong – and the pain won’t go away until you treat the problem.

Even if you don’t have a full-blown kidney infection, the inflammation and tenderness of an irritated kidney can set off major back pain. Watch for collaborating symptoms – frequent bathroom trips, burning and sharp pains in your side – and don’t miss the message your back is sending!

#5 Diabetes

Who knew back could be a short cut to reading your blood sugar levels? It turns out that severe back pain can be a major red flag for diabetes – even more when it’s combined with pain radiating down your leg.

While this type of pain is commonly sciatica, it also could be a symptom of diabetic neuropathy. Diabetes affects the nerves in your body. Left unchecked diabetes can lead to a loss of sensation and range of motion as a result of this nerve damage. Bad cases can mean a total loss of sensation or even amputation below the knee. Don’t let things go that far – hear what your back is telling you and get help.

#6 Multiple Sclerosis

Neck and back pain are both associated with Multiple Sclerosis (MS). The natural progression of the disease often combines this with burning or tingling sensations and is made worse when you also have other inflammation issues.

While pain hasn’t been historically linked to MS, that view is changing. In some patients, it’s a critical marker of the onset of the disease. And if you don’t know why you’re hurting, it certainly pays to make sure your back pain isn’t MS, given the ways MS can be helped – if you catch it at an early stage.

#7 Heart Disease

Back pain can be a warning of major heart trouble – especially in women. While men often experience heart disease and heart attacks in traditional, chest-clutching ways, women tend to experience heart problems differently. Once considered “abnormal” or “atypical,” back pain in the middle to upper back is now commonly accepted as a sign of a heart issue in women.

For both men and women, the pressure of a blocked vein can manifest itself as back pain. If the pressure for the pain seems to be coming from within, and you have other symptoms like shooting pains in your arms, shortness of breath or sudden sweats, don’t ignore your back pain and seek immediate medical assistance.

Fight the pain – AND disease – by fighting the inflammation… FREE!

Look back over this list again. Did you notice that inflammation is a significant part of almost every one of these diseases? It’s also associated with virtually every kind of pain in your body.

Whether your back pain is related to one of these seven serious diseases or not, reducing inflammation in your body can only improve your health and reduce your pain. And it could save your life. Chronic inflammation is a serious problem. But it’s one that you have the power to do something about.

You could take anti-inflammatory drugs, but their list of potential side effects often reads worse than the problem you’re trying to treat. Or, you can do something naturally to fight runaway inflammation.

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From Plastic Wrap to Pyrex, What’s Best?

From Plastic Wrap to Pyrex, What’s Best?

By Jesse Cannone

Food Storage Container

Be sure what you store your food in keeps it safe to eat

New research is constantly discovering new causes of the world’s most deadly diseases – and more often than most people realize, it is due to poor choices in food storage.

Every day, it seems that leached Bisphenol A (BPA) or Polyvinyl Chloride (PVC) is proven a cause for yet another serious health condition, like cancer or organ damage.

Though many companies have responded to research with healthier ways to store food, it is still important to check every container you use for purity and safety. (If you have children in your home, it’s absolutely essential. Children are the most susceptible to the effects of leached toxins.)

From the worst to the best, here are seven popular ways to store food ranked from the worst to the best choice for safety.

 

#7 – Polyvinyl Chloride (PVC)

The absolute worst…

Polyvinyl chloride plastic containers are so dangerous they’ve been nicknamed “toxic plastics.” PVC, or vinyl, is one of the worst ways to store food because it is made with DEHA, a type of chemical softener. According to the EPA, exposure to DEHA can cause liver damage, depleted bone mass, and even cancer.

You can usually identify products containing PVC by its resin identification code (the number with the rotating arrows around it). PVC is marked with a number 3 resin code.

#6 – Polycarbonate

Not as bad, but still nasty…

Most often, the number 7 resin code indicates the presence of polycarbonate—and the presence of a health crisis waiting to happen.

You’re probably aware of the debate between researchers, the plastic industry and the FDA over the safety of BPA in plastic products. BPA has been shown to leach out of plastic products and into the food it contains, causing serious problems because of its ability to mimic the hormone estrogen.

Numerous headlines continue to raise alarms about BPA causing cancer, early onset of puberty and childhood obesity. Yet the FDA maintains it is safe to use, even around children.

While the debate rages on, consumers are forced to come to their own conclusions. Since number 7 coded plastics have been used to make hard baby bottles—and even a slight chance that BPA could harm your infant is too much—it’s best to steer clear of this toxic plastic.

Number 7 plastics are also used to make water bottles, cups, cans and food storage liners.

#5 – Plastic Wrap and Bags

No number? No way!

Plastic wraps, sandwich bags and freezer bags aren’t individually marked with resin codes. However, these plastics are known for containing PVC and BPA and can cause many health problems.

#4 – Polystyrene

“They’re” still not sure…

Polystyrene is found in “Styrofoam” containers commonly used as storage for restaurant leftovers.

According to its annual carcinogen report, the National Toxicology Program insists there’s nothing wrong with polystyrene itself. That’s probably because it doesn’t become poisonous until it’s heated and reverts back to styrene, its toxic basic form. The EPA describes styrene as “a suspected toxin to the gastrointestinal tract, kidney, and respiratory system, among others”.

You’re still better to steer clear of polystyrene. And NEVER attempt to heat your food back up in it.

Polystyrene containers are marked with a number 6 resin code.

#3 – BPA-Free Plastics

Pretty good… but what will cause cancer next?

Many companies have removed Bisphenol A from their plastic formulas in an attempt to make them safer. While the effort is noble, what happens when a few years down the line we find out that some other chemical in plastic is even worse for our health than BPA or PVC combined?

In general, it just seems safer and healthier—especially for kids—to avoid plastic for storing food altogether. But if you must use plastic, BPA-Free is the best choice we know of for now.

#2 – Stainless Steel

Much better, but not without controversy.

New companies are springing up that offer stainless steel food storage containers. Considered far safer than plastics, even this sleek option isn’t entirely without debate.

The stainless steel controversy began when it was first offered as an alternative cookware to cast iron, Teflon and copper— all which leach metals and toxins into food over time.

Stainless steel doesn’t have as many terrifying toxins as the plastics listed above. But it’s important to remember that even “food grade” stainless steel is made of iron alloys combined with chromium and sometimes manganese or nickel.

According to a study that tested the leaching of iron, chromium and nickel into food, “stainless steel utensils may put a reasonable amount of iron and chromium trace element into the diet.” And, it concluded, leached nickel did not exceed the EPA recommended amount.

While the study showed trace amounts of metals being leached, avoiding anything that comes apart in your food is a healthy rule of thumb.

#1 – Borosilicate Glass with a Glass Top

The Best Way to Store Food!

Glass is a completely inactive material—it won’t react with food, it won’t deteriorate and it won’t absorb bacteria or toxins. It is also one of the greenest container solutions available since it is 100% recyclable.

Borosilicate glass specifically holds up to extreme temperature changes much better than other types of glass.

Of course, glass is nothing new—it has been used for centuries for everything from jarring harvested fruits to your favorite 9×13 casserole dish. But as a storage option, it hadn’t been perfected until recently.

Because you don’t want any plastic—BPA-free or not—touching your food, the standard airtight lid isn’t going to cut it. The absolute best option would be a glass-on-glass bottom and top set—of course, that’s impossible.

Thankfully, many companies such as Pyrex have come out with a glass-on-glass container solution that uses a silicone rim to maintain an airtight seal to prevent premature spoilage. This is, in our opinion, the healthiest way to store food available today.

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10 Top Tips To Your Ideal Physique By Tirrel Grant

 

By Tirrel Grant

1. You can’t out train a bad diet

No matter how hard you train there is no magical workout program that will give you optimal results with a poor diet. A structured well balanced diet will increase your performance in the gym, sustain energy levels and set you on your way to a lean physique. Look at it this way, how many hours a day do you train? Now how many hours a day can you potentially fuel your body with nutrient dense foods?

2. Give your body reason to change

When you are in the gym you need to be training at a high-intensity and apply progressive overloads into your workouts (lift heavier) So that your body has to adapt to the training stimulus and get stronger. A quick and easy way of doing this can be as simple as manipulating your rep tempo and rest periods, you’ll be surprised at the changes you will begin to see.

3. Have a set goal

Having a set goal is a great way of self-motivation, knowing what you want to achieve and picturing the end result. However your goals need to be specific measurable and within the timeframe you want to get lean? How lean and by when? Setting specific goals takes commitments and to achieve you need to be committed and if you want it bad enough you will succeed.

4. Always have Protein based breakfast

I have always lived by a protein-based breakfast; having a protein breakfast will slowly increase energy level without rapidly spiking insulin levels. You will feel fuller and more alert for extended periods of time, you will increase your energy levels without worrying about fat storage. Give it a try its great I did this throughout the whole of my competition prep, the difference noticed since applying this to my diet have been simply amazing.

Fail to prepare and be prepared to fail.

When setting out on a new or planned eating program preparation is a must! Whether it means getting up 20 mins earlier in the morning or while cooking dinner you cook for the following day too. If you don’t have the willpower to add an additional 20 mins to your evening or morning to achieve your goal you don’t want it enough. 20 mins of prep for 12 hours of clean eating I’ll settle for that any day!

6. Reward yourself

It is always good to reward hard work and efforts, the main thing with this is to be honest with yourself. Did you give every session your all and leave the gym with nothing left in the tank? Did you give your eating plan 110%, when tested did you opt for the healthier alternative? If your answers are yes then at a scheduled time and date your should reward your efforts. Rewards are a great way to make your ragtime liveable long term and your results paramount.

7. Planned periodisation

A big mistake people commonly make is chopping and changing between different workout plans or not sticking to the same program for long enough. Variety is essential yes! But how will you improve a lift, know your getting stronger, fitness levels and recovery improving if you only do it once or twice a month? Try giving yourself 4-6 weeks on a program, manipulate the reps, rest intervals and you will be on to a winner.
Give your body time to adapt.

Hiit training

I will be honest I am not the biggest fan of cardio but hey sometimes it needs
To be done. It goes back to what I mentioned earlier “make intensity key”. Keep the sessions short but intense work at a high thresholds maximum intensity vs maximum recover. Interval training is awesome for burning fat when done right, I hit some HIIT throughout my prep in my 16 week road to my fitness modelling comp I hated every minute but when you have a desire to reach your goals you need to push through pain barriers “give your body a reason to change”

9. Make intensity a priority

Your workout should be kept within 45-mins/1hr make intensity the main factor in your workouts. Often I hear people mention they spent 2 hours in the gym working out sometimes even more! How hard are you really working if you are able to train for that long if endurance is not your goal? Keep your sessions within an hour, limit elevating cortisol levels, the less stress the more optimal your results will be.

10. Rest

Now this is hard even for me, but for optimal results from your training scheduled rest days is a MUST! The rest days are when the most adaptation will take place, as long as you stick to your eating plan you will not get fat or lose muscle! The rest will make you feel stronger and more motivated for your next workout, your body needs rest to allow growth, check out my Ebook and how I planned my workouts and days off.

 

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